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Medchemexpress LLC PHT-7.3 | 1614225-93-2 | 99.3% | 10 MG
SDP

Supplier:  Medchemexpress LLC HY12859010MG

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PHT-7.3 is a selective inhibitor of the connector enhancer of kinase suppressor of Ras 1 (Cnk1) pleckstrin homology (PH) domain, with a Kd of 4.7 μM. It inhibits mutant KRas cancer cell and tumor growth and signaling, without affecting wild-type KRas. PHT-7.3 demonstrates antitumor activity and has shown cytostatic effects in mut-KRas(G12S) A549 and mut-KRasG12V H441 xenograft models at a dosage of 200 mg/kg.

  • Selective inhibitor of Cnk1 PH-domain
  • Inhibits mutant KRas cancer cell and tumor growth
  • Demonstrates antitumor activity
  • Shows cytostatic antitumor activity in mut-KRas xenograft models

Catalog No. 50-003-42020


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