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Apexbio Technology LLC PI-103 Hydrochloride 371935-79-4 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A37245.1
PI-103 Hydrochloride (CAS 371935-79-4) is a dual inhibitor targeting class I phosphatidylinositide 3-kinases (PI3K) and mammalian target of rapamycin (mTOR) It selectively inhibits PI3K isoforms p110 p110 p110 and mTOR with reported IC50 values of 0 002 M 0 003 M 0 003 M and 0 030 M respectively PI-103 effectively blocks the PI3K/Akt/mTOR pathway which is centrally involved in cell proliferation and survival signaling and is frequently dysregulated in cancer In various cellular models including leukemia hepatocellular carcinoma glioblastoma and neuroblastoma PI-103 suppresses pathway activation and inhibits cell proliferation It is widely used for investigating PI3K/Akt/mTOR signaling in oncology research
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