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Apexbio Technology LLC PI-1840 1401223-22-0 50mg
Supplier: Apexbio Technology LLC B475550
PI-1840 (CAS 1401223-22-0) is a potent selective and rapidly reversible noncovalent inhibitor of the proteasome chymotrypsin-like (CT-L) activity It exhibits an IC50 of 27 nM against CT-L catalytic function of the proteasome with significantly greater selectivity over other proteolytic activities including PGPH-L and T-L In MDA-MB-468 human breast cancer cells PI-1840 inhibits CT-L activity (IC50 0 37 M) suppresses cell viability and proliferation and induces accumulation of CT-L substrates such as I B- p27 and Bax ultimately triggering apoptosis via PARP cleavage and caspase-3 activation In vivo PI-1840 markedly reduces tumor growth in a breast cancer xenograft model This compound is valuable for investigating proteasome function apoptosis and cancer biology
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