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Echelon Biosciences Research LabsSupplier Diversity Partner AS604850 (PI3-K gamma Inhibitor 2) 1 mg  DFS Item

Manufacturer:  Echelon Biosciences Research LabsSupplier Diversity Partner B03021MG

5-(2,2-Difluoro-benzo[1,3]dioxol-5-ylmethylene)-thiazolidine-2,4-dione (AS604850) is an inhibitor of PI 3-Kγ with an IC50 = 250 nM. AS604850 is selective for the γ-isoform (IC50: PI 3-Kα = 4.5 μM, PI 3-Kβ, PI 3-Kδ > 20 μM) and shows no notable activity against a wide array of protein kinases at 1 μM.\n\n



\nWater: insoluble, DMSO: 5 mg/mL\n


\nStore dry between 2-8oC. Stock solutions should be stored frozen (-20oC).\n


\n1) M. Camps et al. "Blockade of PI3Kg suppresses joint inflammation and damage in mouse models of rheumatoid arthritis" Nature Medicine, 2005, 11, 936-943.\n\n


\nTechnical Data Sheet

Catalog No. 50-720-014

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