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Echelon Biosciences Research Labs AS605240 (PI3-K gamma Inhibitor 1) 1 mg
Supplier: Echelon Biosciences Research Labs B03011MG
5-quinoxilin-6-methylene-1,3-thiazolidine-2,4-dione (AS605240) is an ATP-competitive inhibitor of PI3-K (IC50 = 8 nM). It is selective for the -isoform (IC50: PI 3-K = 60 nM, PI 3-K = 270 nM, PI 3-K = 300 nM) and shows no notable activity against a wide array of protein kinases at 1 M. In addition, AS605240 suppresses the progression of joint inflammation in a mouse model of rheumatoid arthritis and suppresses inflammation in a mouse model of lupus.nn
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Solubility
nwater: insoluble, DMSO: 2.5 mg/mLnStorage
nstore dry between 2-8oC. Stock solutions should be stored frozen (-20oC).nReferences
n1) M. Camps et al. "Blockade of PI3Kg suppresses joint inflammation and damage in mouse models of rheumatoid arthritis" Nature Medicine, 2005, 11, 936-943. This item is non returnableThe Fisher Scientific Encompass Program offers items which are not part of our distribution portfolio. These products typically do not have pictures or detailed descriptions. However, we are committed to improving your shopping experience. Please use the form below to provide feedback related to the content on this product.