Echelon Biosciences Research Labs PI-103 (PI3-K alpha Inhibitor 1) 1 mg

Supplier:  Echelon Biosciences Research Labs B03031MG

PI-103 is a selective inhibitor for the -isoform of PI 3-Kinase (IC50: PI 3-K = 8 nM, PI 3-K = 88 nM, PI 3-K = 48 nM, PI 3-K = 150 nM). It is also inhibits DNA-PK (IC50 = 2 nM) and mTOR1 and mTOR2 (IC50 = 20 & 83 nM). PI-103 shows little activity against a wide array of protein kinases at 10M. PI-103 blocks glioma proliferation by blocking the PI 3-K/Akt pathway in vitro and in vivo. This item is non returnable

Catalog No. 50-720-016