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Sigma Aldrich Fine Chemicals Biosciences PI 3 Kinase p110alphaE542K
Supplier: Sigma Aldrich Fine Chemicals Biosciences 14782
The E542K substitution is a somatic mutation in p110alpha that has been associated with tumours of the colon and brain. Combined in vitro and in vivo studies have shown that this mutation confers higher lipid kinase activity than wild type and is able to induce oncogenic transformation.
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