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Sigma Aldrich Fine Chemicals Biosciences PI3 Kinase p110alpha H1047
Supplier: Sigma Aldrich Fine Chemicals Biosciences 14787
The H1047R substitution in p110alpha is associated with a number of human cancers. The residue is conserved between the human and mouse sequences. In vitro studies have shown that this mutation confers increased lipid kinase activity compared to wild type and is able to induce oncogenic transformation.
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