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Medchemexpress LLC PI3K/Akt/CREB activator 1 (compound AE-18) | 2708177-73-3 | C19H15F4NO3 | 100 MG
Supplier: Medchemexpress LLC HY151527100MG
PI3K/Akt/CREB activator 1 (compound AE-18) is a potent, orally active activator that promotes neuronal proliferation, induces differentiation, and accelerates axon-dendrite polarization. It functions by upregulating brain-derived neurotrophic factor via the PI3K/Akt/CREB pathway and is suitable for research into vascular dementia (VaD).
- Promotes neuronal proliferation
- Induces differentiation of Neuro-2a cells into a neuron-like morphology
- Accelerates axon-dendrite polarization of primary hippocampal neurons
- Upregulates brain-derived neurotrophic factor via the PI3K/Akt/CREB pathway
- Mitigates impairment of learning and memory in chronic cerebral hypoperfusion models
- Alleviates pathological injury in the hippocampus
- Improves cerebral blood flow recovery
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