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Medchemexpress LLC PI3K/Akt/CREB activator 1 (compound AE-18) | 2708177-73-3 | C19H15F4NO3 | 50 MG
Supplier: Medchemexpress LLC HY15152750MG
PI3K/Akt/CREB activator 1 (compound AE-18) is a potent, orally active activator that promotes neuronal proliferation, induces differentiation of Neuro-2a cells, and accelerates axon-dendrite polarization of primary hippocampal neurons. It achieves this by upregulating brain-derived neurotrophic factor via the PI3K/Akt/CREB pathway and is used in vascular dementia (VaD) research.
- Promotes neuronal proliferation and differentiation
- Accelerates axon-dendrite polarization of primary hippocampal neurons
- Upregulates brain-derived neurotrophic factor (BDNF)
- Improves cerebral blood flow recovery in models of chronic cerebral hypoperfusion (CCH)
- Mitigates impairment of learning and memory in CCH models
- Alleviates CCH-induced pathological injury in the hippocampus
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