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Medchemexpress LLC PI3K/AKT-IN-1 | 3033069-84-7 | 99.6% | C23H23N5O4S | 25 MG
SDP

Supplier:  Medchemexpress LLC 25MGHY144806

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PI3K/AKT-IN-1 is an effective dual inhibitor of PI3K and AKT, exhibiting anticancer activity by inhibiting the PI3K/AKT axis and inducing caspase 3-dependent apoptosis. This compound has high cytotoxic activity against leukemia K562 and breast cancer MCF-7 cell lines, and is intended for research use only.

  • Demonstrates high cytotoxic activity, particularly against leukemia cell line K562 (IC50=2.62 μM) and breast cancer cell line MCF-7 (IC50=3.22 μM)
  • Promotes S-phase cell cycle arrest and induces apoptosis in K562 cells
  • Significantly reduces the expression of PI3K, p-PI3K, AKT, p-AKT, Cyclin D1, and NF-κB
  • Found to be non-toxic and well-tolerated in animal studies, with an LD50 greater than 2000 mg/kg
  • Soluble in DMSO at 50 mg/mL
  • Solid, off-white to light yellow appearance

Catalog No. 50-003-57367


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