Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Cayman Chemical PIclamIlast 10mg
Supplier: Cayman Chemical 2917010 MG
A PDE4 inhibitor (IC50 = 0.31 nM); selective for PDE4 over PDE1, PDE2, PDE3, PDE5, and PDE7A in cell-free assays (IC50s = >100, 40, >100, 14, and >10 μM, respectively); inhibits superoxide production by guinea pig eosinophils and histamine-induced contraction in isolated guinea pig trachea (IC50s = 24 and 2 nM, respectively); inhibits eosinophil, neutrophil, lymphocyte, and TNF-α accumulation in bronchoalveolar lavage fluid (BALF) from ovalbumin-sensitized rats (ED50s = 23.8, 14.1, 19.5, and 14.4 μmol/kg, respectively); nhibits eosinophil, neutrophil, lymphocyte, and TNF-α accumulation in BALF from ovalbumin-sensitized rats (ED50s = 23.8, 14.1, 19.5, and 14.4 μmol/kg, respectively); inhibits ovalbumin-induced bronchoconstriction in a guinea pig model of asthma (ED50 = 0.033 mg/kg)
Product Title
By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.
Spot an opportunity for improvement?