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Medchemexpress LLC Pictilisib (dimethanesulfonate) | 957054-33-0 | 99.7% | 705.85 | 200 MG
Supplier: Medchemexpress LLC HY20180200MG
Pictilisib dimethanesulfonate is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM, with modest selectivity against p110β (11-fold) and p110γ (25-fold).
- Potent inhibitor of PI3Kα/δ with IC50 of 3 nM
- Modest selectivity against p110β (11-fold) and p110γ (25-fold)
- Reduces tumor cell viability in breast cancer cell lines
- Inhibits Akt phosphorylation and downstream targets of Akt signaling
- Shows high efficacy of antitumor activity in ZD1839-resistant non-small cell lung cancer (NSCLC) cell lines (A549 and H460)
- Highly efficacious in combination with U0126 in inducing cell growth inhibition, G0-G1 arrest, and cell apoptosis
- Reduces secreted VEGF after hypoxic/anoxic exposure
- Leads to tumor stasis in animal models
- Results in tumor regressions during treatment leading to enhanced antitumor responses
- Reduces tumor growth and PI3K and HIF-1 pathway activity in tumor-bearing mice
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