Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. 5000062633

Apexbio Technology LLC Pifithrin-α (PFTα) 63208-82-2 10mM (in 1mL DMSO)
SDP

Supplier:  Apexbio Technology LLC A42065.1

Encompass_Preferred

Pifithrin- (PFT CAS 63208-82-2) is a synthetic water-soluble inhibitor targeting the tumor suppressor protein p53 Initially identified by its ability to block activation of p53-responsive genes PFT reduces apoptosis in transformed mouse embryonic fibroblasts (expressing E1a and ras) in a p53-dependent manner Additionally PFT prevents DNA damage-induced growth arrest in human diploid fibroblasts and promotes G2-phase cell cycle arrest following -irradiation It also decreases the expression of pluripotency marker Nanog affecting self-renewal potential in embryonic stem cells without compromising viability Thus PFT serves as a valuable research tool to investigate p53-mediated cellular pathways

Catalog No. 50-000-62633


May include imposed supplier surcharges.
Only null left
Add to Cart

Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.