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Medchemexpress LLC Pifithrin-α hydrobromide | 63208-82-2 | C16H19BrN2OS | 100 MG
Supplier: Medchemexpress LLC HY15484100MG
Pifithrin-α hydrobromide is a p53 inhibitor that blocks its transcriptional activity and prevents cells from apoptosis. It also acts as an aryl hydrocarbon receptor (AhR) agonist. It is a water-soluble compound that can suppress p53 protein transcription and block glucose oxidase (GOX)-induced Bcl-2 protein reduction and Bax increase.
- Blocks transcriptional activity of p53
- Prevents cells from apoptosis
- Acts as an aryl hydrocarbon receptor (AhR) agonist
- Suppresses p53 protein transcription
- Blocks GOX-induced Bcl-2 protein reduction and Bax increase
- Induces AhR DNA binding complex formation
- Activates reporter activity
- Up-regulates the classic AhR target gene CYP1A1
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