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Medchemexpress LLC Pifithrin-α hydrobromide | 63208-82-2 | C16H19BrN2OS | 25 MG
SDP

Supplier:  Medchemexpress LLC 25MGHY15484

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Pifithrin-α hydrobromide is a p53 inhibitor that blocks its transcriptional activity and prevents cells from apoptosis. It also acts as an aryl hydrocarbon receptor (AhR) agonist.

  • Suppresses p53 protein transcription
  • Prevents glucose oxidase (GOX)-induced p53 protein increase, Bcl-2 protein reduction, and Bax increase
  • Inhibits p53-dependent apoptosis
  • Acts as a potent AhR agonist, activating reporter activity, and up-regulating the AhR target gene CYP1A1
  • Reduces the percentage of annexin V-positive Foxe3-/- SMCs
  • Significantly reduces the incidence of aortic rupture and intramural hematomas
  • Normalizes aortic diameter and TUNEL-positive cells in surviving Foxe3-/- animals

Catalog No. 50-003-75288


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