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Medchemexpress LLC Pifithrin-α (hydrobromide) | 63208-82-2 | C16H19BrN2OS | 50 MG
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Supplier:  Medchemexpress LLC HY1548450MG

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Pifithrin-α hydrobromide is a p53 inhibitor that blocks its transcriptional activity and prevents cells from apoptosis. It also acts as an aryl hydrocarbon receptor (AhR) agonist.

  • Blocks p53 transcriptional activity.
  • Prevents cells from apoptosis.
  • Acts as an aryl hydrocarbon receptor (AhR) agonist.
  • Suppresses glucose oxidase (GOX)-induced p53 protein increase.
  • Reduces Bcl-2 protein and prevents Bax increase.
  • Up-regulates the classic AhR target gene CYP1A1.
  • Demonstrates in vivo efficacy in reducing aortic rupture and normalizing aortic morphology in Foxe3-/- mice.

Catalog No. 50-003-76601


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