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Medchemexpress LLC Pifithrin-α hydrobromide | 63208-82-2 | C16H19BrN2OS | 500 MG
Supplier: Medchemexpress LLC HY15484500MG
Pifithrin-α hydrobromide is a p53 inhibitor that blocks its transcriptional activity, preventing cells from apoptosis. It also acts as an aryl hydrocarbon receptor (AhR) agonist. This water-soluble compound can suppress p53 protein transcription and glucose oxidase (GOX)-induced p53 protein increase.
- Blocks p53 transcriptional activity
- Prevents cells from apoptosis
- Acts as an aryl hydrocarbon receptor (AhR) agonist
- Suppresses p53 protein transcription
- Blocks GOX-induced Bcl-2 protein reduction and prevents Bax increase
- Binds to AhR and activates reporter activity
- Up-regulates classic AhR target gene CYP1A1
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