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Medchemexpress LLC Pifusertib hydrochloride | 2930090-28-9 | 99.9% | 460.96 | 1 ML
Supplier: Medchemexpress LLC HY19934A10MM/1ML
Pifusertib hydrochloride is a potent, selective, orally active allosteric Akt inhibitor that triggers anti-myeloma activities. It enhances fatal endoplasmic reticulum (ER) stress induced by proteasome inhibition, leading to apoptosis and autophagy.
- Potent, selective, orally active allosteric Akt inhibitor.
- Triggers anti-myeloma activities.
- Enhances fatal endoplasmic reticulum (ER) stress.
- Induces apoptosis and autophagy.
- Blocks basal phosphorylation of Akt and downstream targets in MM cells.
- Induces cytotoxicity in MM cells with high baseline Akt phosphorylation.
- Inhibits tumor growth in murine xenograft models.
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