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Echelon Biosciences Research Labs PIK-93 5 mg
Supplier: Echelon Biosciences Research Labs B03065MG
PIK-93 is the first reported PI4-kinase inhibitor, which is able to inhibit PI4KIII at low-nanomolar range (IC50=19 nM). In addition, this compound is a potent inhibitor of PI3K in vitro (IC50=16 nM). This compound inhibits p110, p110, p110 with IC50s of 0.039, 0.59, 0.12 M respectively. PIK-93 hydrogen bonds to the backbone amide and carbonyl of Val882 and between its sulphonamide and Asp964. PI4KIII is esential for replication of numerous viruses P. falciparum. Inhibition of plasmodial PI4KIII has been proposed as an anti-malaria treatment. This item is non returnable
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