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Medchemexpress LLC PIM-447 (dihydrochloride) | 1820565-69-2 | 99.8% | 513.38 | 1 MG
Supplier: Medchemexpress LLC 1MGHY19322B
PIM-447 dihydrochloride (LGH447 dihydrochloride) is a potent, orally available, and selective pan-PIM kinase inhibitor. With Ki values of 6, 18, and 9 pM for PIM1, PIM2, and PIM3, it displays dual antimyeloma and bone-protective effects, and induces apoptosis. This compound is for research use only.
- Potent, orally available, and selective pan-PIM kinase inhibitor
- Inhibits PIM1, PIM2, and PIM3 with picomolar affinity
- Exhibits dual antimyeloma and bone-protective effects
- Induces apoptosis in multiple myeloma cells
- Increases annexin-V levels and promotes caspase cleavage
- Controls tumor progression in mouse models
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