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Medchemexpress LLC PIM-447 dihydrochloride | 1820565-69-2 | 99.8% | 513.38 | 1 ML
SDP

Supplier:  Medchemexpress LLC HY19322C10MM/1ML

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PIM-447 dihydrochloride (LGH447 dihydrochloride) is a potent, orally available, and selective pan-PIM kinase inhibitor, with Ki values of 6, 18, and 9 pM for PIM1, PIM2, and PIM3, respectively. It displays dual antimyeloma and bone-protective effects and induces apoptosis.

  • Potent, orally available, and selective pan-PIM kinase inhibitor.
  • Exhibits Ki values of 6, 18, and 9 pM for PIM1, PIM2, and PIM3.
  • Displays dual antimyeloma and bone-protective effects.
  • Induces apoptosis.
  • Effective in controlling tumor progression in a mouse model.
  • Well tolerated with no significant body weight decrease.
  • Increases bone volume density and trabecular number.
  • Reduces trabecular separation.

Catalog No. 50-003-85606


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