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Medchemexpress LLC Pioglitazone hydrochloride | 112529-15-4 | 100.0% | C19H21ClN2O3S | 1 ML
Supplier: Medchemexpress LLC HY1460110MM/1ML
Pioglitazone hydrochloride is a potent and selective PPARγ agonist with EC50s of 0.93 and 0.99 μM for human and mouse PPARγ, respectively. It can ameliorate insulin resistance and diabetes, attenuates the loss of body weight and cardiac hypertrophy, reduces elevated serum glucose levels, and improves associated dyslipidemia. In vitro, it completely abrogates AGEs-induced beta cell necrosis and prevents AGEs-induced increment in caspase-3 activation.
- Potent and selective PPARγ agonist
- Ameliorates insulin resistance and diabetes
- Attenuates loss of body weight and cardiac hypertrophy
- Reduces elevated serum glucose levels
- Improves associated dyslipidemia
- Completely abrogates AGEs-induced beta cell necrosis
- Prevents AGEs-induced increment in caspase-3 activation
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