Invitrogen™ Human PIP5K1C, GST Tag Recombinant Protein

Description

Recombinant Protein

For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. This PIP5K1C recombinant human protein (full length) was expressed in insect cells. PIP5K1C recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service. : Validated for use with the Adapta™ assay: Available in multiple pack sizes for convenient use: Also available in our SelectScreen Kinase Profiling Service Protein Form: Full Length, Recombinant, Active The gene accession number for PIP5K1C is NP_036530.1.

PIP5K1C lipid kinase or phosphatidylinositol-4-phosphate 5-kinase 1 gamma phosphorylates phosphatidylinositol-4-phosphate to form phosphatidylinositol 4,5-bisphosphate. PIP5K1C is found at synapses and has been found to play roles in endocytosis and cell migration. PIP5K1C directly associates with -beta-catenin and increases -beta-catenin activity downstream of growth factor stimulation. PIP5K1C expression and kinase activity enhance -beta-catenin phosphorylation on residues that promote nuclear importation and transcriptional activity. PIP5K1C deficiency impairs neutrophil recruitment as a result of defect in adhesion. PIP5K1C regulated the adhesion through facilitation of RhoA GTPase and integrin activation by chemo attractants.

Specifications

• Accession Number: O60331
• Concentration: See Label
• For Use With (Application): Kinase Assay
• Formulation: 50mM tris HCl with 0.25mM DTT, 0.1mM EDTA, 10mM glutathione, 25% glycerol, 150mM NaCl, 0.1mM PMSF and no preservative; pH 7.5
• Gene ID (Entrez): 23396
• Molecular Weight (g/mol): 99.6 kDa
• Name: Human PIP5K1C, GST Tag
• pH Range: 7.5
• Purification Method: Purified
• Quantity: 20 μg
• Storage Requirements: -80°C, Avoid Freeze/Thaw Cycles
• Regulatory Status: RUO
• Gene Alias: AI115456; AI835305; diphosphoinositide kinase; Kiaa0589; LCCS3; phosphatidylinositol 4-phosphate 5-kinase type I gamma; Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma; phosphatidylinositol-4-phosphate 5-kinase; phosphatidylinositol-4-phosphate 5-kinase type 1 gamma; phosphatidylinositol-4-phosphate 5-kinase type I gamma; phosphatidylinositol-4-phosphate 5-kinase type-1 gamma; phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma; phosphatidylinositol-4-phosphate 5-kinase, type I, gamma; Pip5k1c; PIP5K1-gamma; PIP5Kgamma; PIP5K-GAMMA; PIP5KI gamma; Pip5kIgamma; PIP5KI-gamma; PIPKIg_v4; ptdIns(4)P-5-kinase 1 gamma; ptdIns(4)P-5-kinase gamma; ptdInsPKIgamma; type I PIP kinase
• Common Name: PIP5K1C
• Gene Symbol: PIP5K1C
• KinaseFamily: PI3 Kinase
• Product Type: Protein
• Conjugate: Unconjugated
• Species: Human
• Recombinant: Recombinant
• Protein Tag: GST-tag
• Sequence: Full length
• Content And Storage: -80°C, Avoid Freeze/Thaw Cycles
• Shipping Condition: Dry Ice
• Expression System: Insect cells
• Protein Family: Kinases & Inhibitors
• Protein Form: Full Length, Recombinant, Active
• Form: Liquid