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Cayman Chemical PIperazIn ErastIn 10mg
Supplier: Cayman Chemical 3693410 MG
A ferroptosis inducer; inhibits glutamate release in human CCF-STTG1 astrocytoma cells (IC50 = 0.8 µM), indicating inhibition of the system xc- cystine/glutamate transporter; decreases GSH levels in HT-1080 cells at 10 µM; inhibits the growth of H-RasG12V-overexpressing BJeLR cells (IC50 = 0.3 µM); increases hepatic mRNA expression of the gene encoding Cox-2 and prevents tumor formation in an HT-1080 mouse xenograft model at 60 mg/kg
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