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Apexbio Technology LLC Pitolisant hydrochloride 903576-44-3 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A37275.1
Pitolisant hydrochloride (CAS 903576-44-3) also known as BF2 649 or Ciproxidine is a potent and selective non-imidazole inverse agonist of the histamine H3 receptor exhibiting a Ki of 0 16 nM for the human recombinant receptor By targeting the H3 autoreceptor pitolisant modulates histaminergic neurotransmission and regulates the release of other neurotransmitters In vitro it demonstrates higher intrinsic activity than ciproxifan and an EC50 of 1 5 nM Pitolisant is orally bioavailable and increases brain tele-methylhistamine levels in rodents in a dose-dependent manner reflecting activation of histaminergic neurons It is widely applied in studies related to cognition epilepsy and models of neuropsychiatric disorders
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