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Apexbio Technology LLC PJ34 hydrochloride 344458-15-7 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A41595.1
PJ34 hydrochloride (CAS 344458-15-7) is a small molecular inhibitor targeting poly(ADP-ribose) polymerase (PARP) an enzyme critical for DNA repair and cellular proliferation In vitro assays demonstrate dose-dependent inhibition of purified PARP activity with an EC50 of approximately 20 nM Unlike other inhibitors such as 3-aminobenzamide (3-AB) PJ34 lacks antioxidant properties and exhibits significantly higher inhibitory potency against PARP Experimental studies have shown PJ34 protects against peroxynitrite-induced cell necrosis (EC50 20 nM) and dose-dependently suppresses proliferation in HepG2 liver cancer cell lines enhancing chemotherapeutic efficacy and conferring neuroprotection in various disease models
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