Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. 5000342938

Medchemexpress LLC PK11007 | 874146-69-7 | 98.7% | 10 MG
SDP

Catalog No. 5000342938
Encompass_Preferred

PK11007 is a mild thiol alkylator with anticancer activity. It stabilizes p53 through selective alkylation of two surface-exposed cysteines without affecting its DNA binding activity. PK11007 also induces cell death in mutant p53 cancer cells by increasing reactive oxygen species (ROS) levels.

  • Reduces viability significantly in mutant p53 cell lines
  • Induces mainly caspase-independent cell death
  • Up-regulates protein levels of p53 target genes (p21, MDM2, PUMA)
  • Increases p53 activity
  • Increases transcription of p53 target genes
  • Elevates ROS levels
  • Inhibits cell proliferation, induces apoptosis, and alters genes involved in cell death

Catalog No. 50-003-42938 Supplier Medchemexpress LLC Supplier No. HY12878410MG
May include imposed supplier surcharges.
Add to Cart
Add to Cart

missing translation for 'validMainframeMsg'

PK11007 is a mild thiol alkylator with anticancer activity. It stabilizes p53 through selective alkylation of two surface-exposed cysteines without affecting its DNA binding activity. PK11007 also induces cell death in mutant p53 cancer cells by increasing reactive oxygen species (ROS) levels.

  • Reduces viability significantly in mutant p53 cell lines
  • Induces mainly caspase-independent cell death
  • Up-regulates protein levels of p53 target genes (p21, MDM2, PUMA)
  • Increases p53 activity
  • Increases transcription of p53 target genes
  • Elevates ROS levels
  • Inhibits cell proliferation, induces apoptosis, and alters genes involved in cell death

Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.