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Enzo Life Sciences PKC-412 (1mg). CAS: 120685-11-2
Supplier: Enzo Life Sciences BMLEI3700001
Inhibitor of a variety of serine/threonine and tyrosine kinases, like protein kinase C (PKC), cyclic AMP-dependent protein kinase (PKA), S6 kinase, Akt (protein kinase B; PKB), epidermal growth factor receptor (EGFR) tyrosine kinase activity and others including KDR, VEGFR, PDGFR, c-kit and other receptor tyrosine kinases. Potently inhibits FLT-3 kinase including mutant forms found in acute myeloid leukemia in vitro and in vivo. Apoptosis inducer. Showed broad antiproliferative activity against various tumor cell lines. Selectively inhibits T lymphocyte production of TNF-α. Upregulates endothelial nitric oxide synthase (eNOS; NOS III). Abrogates tumor angiogenesis in vivo. Alternative name: 4'-N-Benzoyl-staurosporine, Midostaurin, CGP 41251. Purity: ≥98% (TLC). Solubility: Soluble in DMSO (15mg/ml), MDC (10mg/ml), methanol (5mg/ml) or 100% ethanol (2.5mg/ml). Long Term Storage: -20°C.
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