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Medchemexpress LLC PKC-theta inhibitor 1 | 1160501-81-4 | 99.7% | 348.32 g·mol⁻¹ | C17H15F3N4O | 1MG
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Supplier:  Medchemexpress LLC HY1263281MG

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PKC-theta inhibitor 1 is an orally active, selective ATP-competitive inhibitor of protein kinase C theta (PKCθ) intended for preclinical research. It exhibits high binding potency (Ki = 6 nM), suppresses T-cell-mediated release of proinflammatory cytokines in cellular assays (IL-2 IC50 = 0.21 μM; IL-17 IC50 = 1 μM), and has molecular formula C17H15F3N4O with a molecular weight of 348.32 g·mol⁻¹. For research use only.

  • Selective ATP-competitive inhibition of PKCθ with high binding potency.
  • Demonstrated cellular activity against IL-2 and IL-17 production.
  • Orally active compound with in vivo efficacy in autoimmune models.
  • High chemical purity suitable for research applications.
  • Available in small pack sizes for dose-ranging and pilot studies.

Catalog No. 50-002-36653


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