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Cayman Chemical PKI-179hydrochlorIde 5mg
Supplier: Cayman Chemical 212025 MG
A dual PI3K and mTOR inhibitor; inhibits PI3K (IC50s = 8, 24, 17, and 74 nM for isoforms α, β, δ, and γ, respectively); inhibits PI3Kα mutants, E545K and H1047R (IC50s = 14 and 11 nM, respectively); inhibits mTOR (IC50 = 0.42 nM); antiproliferative against MDA-361 (breast) and PC3MM2 (prostate) cell lines (IC50s = 22 and 29 nM, respectively); inhibits tumor growth in MDA-361 mouse xenografts (50 mg/kg)
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