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Apexbio Technology LLC PKI-402 1173204-81-3 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A85055.1
PKI-402 (CAS 1173204-81-3) is an ATP-competitive inhibitor targeting class I PI3Ks (PI3K ) with IC50 values of 1 nM 7 nM 16 nM and 14 nM respectively PI3Ks are enzymes central to the PI3K/Akt/mTOR signaling pathway impacting cellular proliferation survival differentiation and migration processes critically involved in cancer progression PKI-402 reduces cell growth and phosphorylation of PI3K/mTOR downstream signaling proteins in human tumor cell lines including breast glioma pancreatic and non-small cell lung cancers In xenograft mouse models (MDA-MB-361) PKI-402 administration suppresses Akt phosphorylation triggers apoptosis (PARP cleavage) and inhibits tumor growth highlighting its significance for cancer biology research
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