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Apexbio Technology LLC PKR Inhibitor 608512-97-6 5mg
Supplier: Apexbio Technology LLC C44395
PKR Inhibitor (CAS 608512-97-6) is a small molecule that selectively inhibits double-stranded RNA-dependent protein kinase (PKR) a critical regulator of translational initiation via kinase-dependent phosphorylation events With reported IC50 values of 186 210 nM this inhibitor blocks PKR autophosphorylation thereby alleviating PKR-mediated translational repression in vitro In SH-SY5Y cells PKR Inhibitor mitigates Ab-induced caspase 3 activation and protects against endoplasmic reticulum stress-associated neuronal cell death In animal models systemic administration suppresses the apoptotic PKR/eIF2 pathway without activating the mTOR/p70S6K cascade PKR Inhibitor is utilized in studies of translational control stress responses and neuroprotection mechanisms
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