Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
STEMCELL Technologies Human Recombinant PDGF-BB, ACF, Size: 1000 µg
Supplier: STEMCELL Technologies 78154.2
Use platelet-derived growth factor (PDGF) BB to induce mesenchymal stem cell migration, angiogenesis, and osteogenesis (Xie et al. Nat Med, 2014). PDGF is a dimeric glycoprotein that can be assembled as heterodimers (PDGF-AB) or homodimers (PDGF-AA and PDGF-BB) (Westermark & Heldin. Acta Oncol, 1993). This glycoprotein signals through the receptor tyrosine kinases PDGFRα and PDGFRβ. PDGF is a potent mitogen for cells of mesenchymal origin and induces migration through signaling pathways involving MEK/ERK, EGFR, Src, and PI3K/AKT (Kim et al. Growth Factors, 2007). PDGF-BB is secreted by osteoblasts and preosteoclasts during bone modeling and remodeling (Xie et al.). Human recombinant PDGF-BB from STEMCELL is animal component-free and comes lyophilized with ≥ 95% purity; EC50 ≤ 20 ng/mL; endotoxin levels verified ≤ 1 EU/μg protein. Alternative names: GDGF, Glioma-derived growth factor, ODGF, Osteosarcoma-derived growth factor, Platelet-derived growth factor-BB.
This item is not returnable.
View return policy
Product Title
By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.
Spot an opportunity for improvement?