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Medchemexpress LLC Plicamycin (Mithramycin A) | 18378-89-7 | MFCD00135618 | 99.46% | C52H76O24 | 50 MG
Supplier: Medchemexpress LLC HYA012250MG
Plicamycin (Mithramycin A) is a selective specificity protein 1 (Sp1) inhibitor that inhibits the growth of various cancers by decreasing Sp1 protein. It also inhibits GSTM2 promoter activity and protein expression. It has demonstrated antitumorigenic activity in xenograft models, reducing tumor volume and weight with minimal toxicity.
- Selective specificity protein 1 (Sp1) inhibitor
- Inhibits growth of various cancers by decreasing Sp1 protein
- Inhibits GSTM2 promoter activity and protein expression
- Induces proteasome-dependent degradation of Sp1 protein
- Suppresses cervical cancer growth via a DR5/caspase-8/Bid signaling pathway
- Demonstrates concentration-dependent inhibition of HEp-2 and KB cell growth
- Causes significant DNA fragmentation
- Antitumorigenic activity in xenograft models
- Reduces tumor volume and weight with minimal toxicity
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