Cayman Chemical PLX5622hemIfumarate 10mg

Supplier:  Cayman Chemical 3627710 MG

A brain-penetrant CSF1R inhibitor (IC50 = 0.016 µM); selective for CSF1R over FLT3, Kit, Aurora C, and VEGFR2 (IC50s = 0.39, 0.86, 1, and 1.1 µM, respectively); greater than 100-fold selective for CSF1R over a panel of 230 kinases; reduces the number of Iba-1+ cells in the spinal cord dorsal horn in a mouse model of neuropathic pain induced by partial ligation of the sciatic nerve at 65 mg/kg; decreases macrophage levels of TNF-α and IL-1β and infiltration in the sciatic nerve and alleviates mechanical and cold allodynia in the same model; decreases the number of hippocampal microglia by 90%, as well as reduces the number and volume of retrosplenial and somatosensory cortical Aβ plaques in the 5XFAD mouse model of Alzheimer's disease at 1,200 ppm in the chow

Catalog No. 50-291-2466