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Apexbio Technology LLC 12-O-tetradecanoyl phorbol-13-acetate (PMA),5mgCAS# 16561-29-8
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Supplier:  Apexbio Technology LLC N20605

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12-O-tetradecanoyl phorbol-13-acetate (TPA) is an activator of ERK/MAPK with the concentration of 50μm [1].ERK is an extracellular signal-regulated kinase and transfers signals from a receptor on the cell surface to DNA cooperated with MAPK. It is reported that ERK deficiency leads to the cell uncontrolled growth and is regarded as a target to cure cancers.TPA is a potent ERK activator. When tested with A549 cells (human lung cancer cell line), TPA treatment led to an early, strong, and relatively transient ERK phosphorylation [2]. In mouse embryo fibroblasts from DUSP5 (+/+) mice, administration of TPA increased levels of ERK expression [3]. Other sizes are also available. Please inqury us for quote.

Catalog No. 50-223-9962


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