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Biogenex Laboratories PMSA: EP192 : 6mL
Supplier: Biogenex Laboratories AN7145M
PSMA(prostate specific membrane antigen) is a type II, integral membrane glycoprotein, composed of a 19 amino acid intracellular domain containing the N-terminus, a 24 amino acid transmembrane region, and a 707 amino acid extracellular C-terminal domain PSMA has two enzymatic activities, one as a prostate-specific integral membrane folate hydrolase and the other as a carboxypeptidase An antibody to PSMA labels normal prostate epithelial cells and prostate tumor cells. Although the expression of PSMA in neovasculature of a variety of solid tumors has been reported, PSMA expression is highly restricted to the prostate. It is a useful marker for prostate tumors. In prostate cancer, overexpression of PSMA is correlated with high tumor grade, non-diploid tumors, andadvanced tumor stage .It can be used as an effective predictor for tumor progression in prostate cancer.
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