Medchemexpress LLC PMX 205 Trifluoroacetate | 99.50% | 953.06 | 1 ML

Supplier:  Medchemexpress LLC HY110136100MG

The product is a specific complement C5aR1 isoform antagonist. It has been investigated for its effects in various in vitro and in vivo models. In vitro studies demonstrate its ability to inhibit the activation of microglia and astrocytes by C5a. In animal models, it has shown efficacy in extending survival time and reducing motor scores, as well as decreasing pathological markers such as fibrillar plaque load and hyperphosphorylated tau.

• Functions as a specific complement C5aR1 isoform antagonist.
• Reduces C5a-induced increases in cell markers and proliferation in a dose-dependent manner.
• Extends survival time in animal models.
• Decreases astroglial proliferation in the lumbar spinal cord in animal studies.
• Reduces fibrillar plaque load in animal models.
• Significantly lowers hyperphosphorylated tau levels in animal models.

Catalog No. 50-003-45038