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Cayman Chemical PMX53trIfluoroACTAte salt 10mg
Supplier: Cayman Chemical 3584010 MG
A C5a receptor antagonist (IC50 = 0.3 µM); inhibits C5a-induced secretion of MPO in isolated human PMNs; inhibits vascular leakage, PMN infiltration, and peritoneal TNF-α and IL-6 production in a rat model of peritoneal Arthus reaction at 10 mg/kg; reduces body weight loss and anorexia and inhibits striatal degeneration in a rat model of 3-NP-induced Huntington’s disease; reduces atherosclerotic lesion size and lipid content in ApoE-/- mice at 3 mg/kg
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