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Medchemexpress LLC PNC-27 acetate | 99.98% | 4031.73 (free base) | 10 MG
Supplier: Medchemexpress LLC HYP3508A10MG
PNC-27 acetate is a chimeric p53-penetratin peptide that binds to HDM-2 in a p53 peptide-like structure, inducing selective membrane-pore formation and leading to cancer cell lysis. It is an anticancer peptide that can be used in acute myeloid leukemia research.
- Binds to HDM-2 in a p53 peptide-like structure.
- Induces selective membrane-pore formation.
- Leads to cancer cell lysis.
- Anticancer peptide.
- Can be used in acute myeloid leukemia research.
- Induces cancer cell death (e.g., 100% cell death in MIA-PaCa-2 cells in 90 minutes at 50 μg/mL).
- Shows anti-leukemia activity in mice (e.g., reduced AML engraftment and prolonged survival at 40 mg/kg intraperitoneal injection once daily for 2-3 weeks).
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