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Medchemexpress LLC PNR-7-02 | 1633660-76-0 | 98.0% | 445.92 g·mol⁻¹ | C24H16ClN3O2S | 25 MG
Supplier: Medchemexpress LLC HY11766425MG
PNR-7-02 is a small-molecule inhibitor of DNA polymerase eta (Pol η) used in research on translesion synthesis and polymerase-mediated drug resistance. It is an indole thio-barbituric acid derivative reported to inhibit Pol η (IC50 ≈ 8 μM) and to act synergistically with cisplatin in cancer cell lines.
- Inhibits Pol η with reported IC50 ≈ 8 μM
- Also shows activity against hRev1 and hpol λ
- High purity (98.0%) suitable for biochemical assays
- Available as a 25 MG package, other sizes available
- Indole thio-barbituric acid scaffold, useful as a small-molecule probe
- For research use only; not for human or clinical use
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