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Medchemexpress LLC PNU 37883 hydrochloride (PNU 37883A) | 57568-80-6 | 99.7% | 381.98 | 50 MG
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Supplier:  Medchemexpress LLC HY10858910MG

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PNU 37883 hydrochloride (PNU 37883A) is a selective vascular ATP-sensitive potassium (Kir6, KATP) channels blocker. This compound has diuretic effects with specific binding in kidney and vascular smooth muscle rather than in brain or pancreatic beta cells.

  • Inhibits four types of KATP channels in HEK-293 cells, including Kir6.2/SUR1, Kir6.2/SUR2A, Kir6.2/SUR2B, or Kir6.1/SUR2B.
  • Inhibits putative smooth muscle KATP channel types, Kir6.2/SUR2B (IC50 of 15 μM) and Kir6.1/SUR2B (IC50 of 6 μM).
  • Significantly inhibits currents generated by expressing Kir6.2Δ26 alone, with an IC50 of 5 μM, which is increased to 38 μM when expressed with SUR2B.
  • Produces a concentration-dependent attenuation of the relaxation of agmatine (100 μM) in phenylephrine- or KCl- precontracted aortic rings.
  • Does not modify vascular tone when used alone at 10 nM.

Catalog No. 50-003-46212


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