Cayman Chemical Podocarpus totara Totarl 50mg

Supplier:  Cayman Chemical 2641250 MG

A diterpene with diverse biological activities; active against Gram-positive bacteria, including P. acnes, S. mutans, B. subtilis, and B. ammoniagenes (MICs = 0.39, 0.78, 1.56, and 0.78 UG/ml, respectively), as well as penicillin-resistant and -susceptible strains of S. aureus (MICs = 0.78 and 1.56 UG/ml, respectively); inhibits mitochondrial respiration in P. aeruginosa; inhibits Fe(III)-ADP/NADPH-induced lipid oxidation in rat liver microsomes and mitochondria (IC50s = 4.79 and 0.47 µM, respectively) and autooxidation of linoleic acid (IC50 = 9.8 µM); increases Akt and GSK-3β phosphorylation at 5 µM and prevents glutamate- or oxygen and glucose deprivation-induced neuronal cell death in rat primary cerebellar granule cells; reduces infarct volume in a rat model of acute cerebral ischemic injury at 1 and 10 UG/kg

Catalog No. 50-293-5384