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Medchemexpress LLC Polθ-IN-4 | 3043810-73-4 | 98.7% | 501.84 | 1 ML
SDP

Catalog No. 5000392671
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Polθ-IN-4 is an orally active prodrug of a DNA polymerase θ (Polθ) inhibitor. It inhibits Polθ activity by targeting its ATP-dependent helicase domain, with Kms of 3.7, 3.7, and 5.2 μM in human, mouse, and rat recombinant alkaline phosphatases, respectively.

  • Demonstrates significant anti-tumor activity in multiple animal experiments.
  • Can be used for studies related to breast cancer and ovarian cancer.
  • Shows robust combination efficacy with Niraparib in HR deficient PDX models in mice and produces 100% tumor regressions in HR deficient human cell line xenograft models when combined with Niraparib.
  • Also induces significant tumor volume difference with Olaparib.
  • Intended for research purposes only.

Catalog No. 50-003-92671 Supplier Medchemexpress LLC Supplier No. HY16191610MM/1ML
May include imposed supplier surcharges.
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Polθ-IN-4 is an orally active prodrug of a DNA polymerase θ (Polθ) inhibitor. It inhibits Polθ activity by targeting its ATP-dependent helicase domain, with Kms of 3.7, 3.7, and 5.2 μM in human, mouse, and rat recombinant alkaline phosphatases, respectively.

  • Demonstrates significant anti-tumor activity in multiple animal experiments.
  • Can be used for studies related to breast cancer and ovarian cancer.
  • Shows robust combination efficacy with Niraparib in HR deficient PDX models in mice and produces 100% tumor regressions in HR deficient human cell line xenograft models when combined with Niraparib.
  • Also induces significant tumor volume difference with Olaparib.
  • Intended for research purposes only.

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