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Cell Signaling TechnologySupplier Diversity Partner Phospho-beta-Catenin (Ser45) Antibody 100 ul DFS Item

Manufacturer:  Cell Signaling TechnologySupplier Diversity Partner 9564S

9564S , β-Catenin is a key downstream effector in the Wnt signaling pathway (1). It is implicated in two major biological processes in vertebrates: early embryonic development (2) and tumorigenesis (3). CK1 phosphorylates β-catenin at Ser45. This phosphorylation event primes β-catenin for subsequent phosphorylation by GSK-3β (4-6). GSK-3β destabilizes β-catenin by phosphorylating it at Ser33, Ser37, and Thr41 (7). Mutations at these sites result in the stabilization of β-catenin protein levels and have been found in many tumor cell lines (8).

Catalog No. 50-194-850


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