Sigma Aldrich Polyester bis-MPA dendron

Catalog No.	Quantity
90-137-6100MG	100 mg

Catalog No. 90-137-6100MG Supplier Sigma Aldrich Supplier No. 901376100MG

Description

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Polyester bis-MPA dendron (8 acetylene, 1 NHBoc (core), generation 3), a high generation dendron, is synthesized by using anhydride activated bis-MPA monomers via divergent growth. It has a large and exact number of reactive groups and has dual functionalization capacity that makes it useful as a high-value scaffold.Bis-MPA (or 2,2-Bis(methylol)propionic acid) is an aliphatic, pro-chiral molecule comprised of two hydroxyls and one carboxylic group that has been used in the synthesis of many different types of polymers. Dendrons synthesized from bis-MPA are biodegradable and have low cytotoxicity, making them well suited for use in biological research applications. These materials have been used in many applications such as signal amplification in bioassays and in drug delivery applications. These alkyne-functionalized dendrimers can be readily functionalized using either copper(I)-catalysed alkyne-azide cycloaddition (CuAAC), strain-promoted alkyne-azide cycloaddition (SPAAC), or thiol-yne click reactions. Additionally, the amine-functionalized core can be readily used in EDC or DCC coupling reactions (after Boc deprotection) with carbonyl-containing compounds to yield highly functionalized materials for a variety of biomedical applications.

Specifications

• Molecular Formula: C107H135NO53
• Linear Formula: C107H135NO53
• Quantity: 100 mg
• Synonym: PFd-G3-BOCNH-Acetylene; bis-MPA dendron
• Molecular Weight (g/mol): 2283.19