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Cayman Chemical Polygalaxnthon III 10mg
Supplier: Cayman Chemical 3062110 MG
A modulator of RORY and LXR receptors an inverse agonist of RORY (IC50 100 nM) and an agonist of LXR binds to PPARY (IC50 209 nM) but does not activate it inhibits LPS-induced expression of TREM-1 in RAW 264 7 cells at 10 M inhibits LPS-induced expression of the LXR target genes IL-6 and IL-33 and increases expression of ABCG1 FASN and SCD-1 in RAW 264 7 cells reduces severity score in a mouse model of collagen-induced arthritis at 20 mg/kg twice per day reduces blood glucose levels in a glucose tolerance test serum levels of total cholesterol and LDL body weight and fat mass in a mouse model of high-fat diet-induced obesity
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