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Medchemexpress LLC Pomalidomide-C3-adavosertib | 2414418-49-6 | MFCD11593005 | 99.8% | 799.88 | C42H45N11O6 | 5 MG
Supplier: Medchemexpress LLC HY1336185MG
Pomalidomide-C3-adavosertib is a proteolysis targeting chimera (PROTAC) that drives CRBN-mediated degradation of the Wee1 kinase, producing rapid target knockdown and downstream antiproliferative effects in cancer cells. It induces DNA damage and apoptosis, and has utility in cellular pharmacology and mechanism-of-action studies, including combination experiments that probe synergy with DNA damage response inhibitors.
- Rapid and selective Wee1 degradation (IC50 = 3.58 nM).
- Antiproliferative activity in MOLT-4 cells (IC50 = 390 nM).
- CRBN-dependent ubiquitin-proteasome mechanism of action.
- Induces DNA damage, apoptosis, and G2/M checkpoint deregulation.
- Suitable for in vitro target validation and cellular pharmacology assays.
- Stable as a powder when stored under recommended conditions.
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