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Medchemexpress LLC Ponatinib (hydrochloride) | 1114544-31-8 | 99.8% | 569.02 | 10 MG
Supplier: Medchemexpress LLC HY10876610MM/1ML
Ponatinib hydrochloride is a hydrochloride of ponatinib, an orally active multi-targeted kinase inhibitor. It targets Abl, PDGFRα, VEGFR2, FGFR1, and Src with various IC50s.
- Reduces the viability, migration, and function of human endothelial cells.
- Decreased cell viability in HUVEC cells in a dose-dependent manner.
- Increased the percentage of annexin/PI labeled cells in HUVEC cells.
- Reduced VEGF-induced migration in HUVEC cells.
- Protects mice from lethal influenza infection by inhibiting cytokine storm.
- Treated mice had higher survival rates and reduced the infiltration of neutrophils.
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